Clinical Information 39 years with abnormal bleeding Test Performed PAP SMEAR Conventional Specimen AdequacySatisfactory for evaluation; endocervical/transformation zone component present Interpretation (Abnormal)AIS Credit: Abdulellah Atia Alshareef, CT(IAC), CT(ASCP)
Test PerformedSurePath™ PAP SMEAR Specimen AdequacySatisfactory for evaluation; endocervical/transformation zone component present Interpretation (Abnormal)High-grade Squamous Intraepithelial Lesion (HSIL) Credit: Moammar M. Mudhaffar, MSc, CT(IAC), CT(ASCP)
Pap smear: – Cellular Changes Consistent with Herpes Simplex – Large multinucleated epithelial cells with 3Ms; Multinucleation, Molding, and Margination of chromatin. – Nuclei have a “ground-glass” appearance Credit: Abdulaziz Asiri, MSc, CT(ASCP), HTL(ASCPi)
Endocervical Adenocarcinoma – Abundant abnormal cells, typically with columnar configuration. – Enlarged, pleomorphic nuclei demonstrate irregular chromatin distribution, chromatin clearing, and nuclear membrane irregularities. – Macronucleoli. – Cytoplasm is finely vacuolated. Credit: Abdulaziz Asiri, MSc, CT(ASCP), HTL(ASCPi)
Routine Pap smear . Lower uterine segments (LUS ) , showing both epithelial and stromal components. Credit: Abdulelah Attiah, CT(ASCP), CTIAC
Pap smear from a 53 patient with a known history of gastric cancer Microscopic Description: Loosely cohesive cluster and single atypical cells exhibiting hyperchromatic eccentric crescent shape nuclei ,coarse chromatin, irregular contour ,prominent nucleoli and vacuolated cytoplasm. Credit: Abdulelah Attiah , CT(ASCP),CTIAC
Sneaky! There were many other similar cells in this SurePath pap. High-grade squamous intraepithelial lesion (HSIL). Credit: Dr. Yazeed Alwelaie
Microscopic description Atypical squamous cells exhibiting enlarged nuclei (>3x normal intermediate squamous cells), irregular nuclear membrane contours, hyperchromasia and perinuclear halo (koilocytic changes). Interpretation Low grade Squamous Intraepithelial Lesion (LSIL) Credit Abdulaziz Assiri, MSc, CT(ASCPi)HTL Aisha Althenian, MSc, CT(ASCP)
